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Regulation of the Contractile Cycle in Smooth Muscle

Regulation of the Contractile Cycle in Smooth Muscle PDF Author: Takeshi Nakano
Publisher: Springer Science & Business Media
ISBN: 4431658807
Category : Medical
Languages : en
Pages : 239
Book Description
At the Mie International Symposium held in Japan in April 1994, leading scientists reviewed recent advances in the understanding of the contractile mechanism in smooth muscle. The present volume collects the papers presented at the symposium, summarizing the latest advances in smooth muscle function and emphasizing important components of the contraction-relaxation cycle. Topics include a discussion of the smooth muscle cell membrane, with emphasis on its ion channels; the regulation of cytosolic Ca2+ levels and the relationship to force in smooth muscle; aspects of the two key regulatory enzymes involved with myosin phosphorylation-dephosphorylation; the molecular basis for pharmacomechanical coupling in smooth muscle; developments in the basic contractile mechanisms involving the crossbridge cycle of tonic and phasic muscle; the role of myosin light chains; and many others. The approach is broad and presents contemporary opinions in pharmacology, physiology, and biochemistry as they relate to smooth muscle function. The book will appeal not only to those working in these disciplines, but to vascular clinicians, obstetric-gynecological physicians, and gastroenterologists as well.

Regulation of the Contractile Cycle in Smooth Muscle

Regulation of the Contractile Cycle in Smooth Muscle PDF Author: Takeshi Nakano
Publisher: Springer Science & Business Media
ISBN: 4431658807
Category : Medical
Languages : en
Pages : 239
Book Description
At the Mie International Symposium held in Japan in April 1994, leading scientists reviewed recent advances in the understanding of the contractile mechanism in smooth muscle. The present volume collects the papers presented at the symposium, summarizing the latest advances in smooth muscle function and emphasizing important components of the contraction-relaxation cycle. Topics include a discussion of the smooth muscle cell membrane, with emphasis on its ion channels; the regulation of cytosolic Ca2+ levels and the relationship to force in smooth muscle; aspects of the two key regulatory enzymes involved with myosin phosphorylation-dephosphorylation; the molecular basis for pharmacomechanical coupling in smooth muscle; developments in the basic contractile mechanisms involving the crossbridge cycle of tonic and phasic muscle; the role of myosin light chains; and many others. The approach is broad and presents contemporary opinions in pharmacology, physiology, and biochemistry as they relate to smooth muscle function. The book will appeal not only to those working in these disciplines, but to vascular clinicians, obstetric-gynecological physicians, and gastroenterologists as well.

Signal Transduction and Smooth Muscle

Signal Transduction and Smooth Muscle PDF Author: Mohamed Trebak
Publisher: CRC Press
ISBN: 1351650610
Category : Medical
Languages : en
Pages : 412
Book Description
All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of smooth muscle cells. Smooth muscle cells respond to numerous inputs, including pressure, shear stress, intrinsic and extrinsic innervation, hormones and other circulating molecules, as well as autocrine and paracrine factors. This book is a review of smooth muscle cell regulation in the cardiovascular, reproductive, GI, and other organ systems with emphasis on calcium and receptor signaling. Key selling features: Focuses on smooth muscles of different types Describes ion channel signaling mechanisms Reviews calcium and receptor signaling Includes novel, cutting-edge methodologies Summarizes studies of mice with genetically encoding sensors in smooth muscle

Ionic Actions on Vascular Smooth Muscle

Ionic Actions on Vascular Smooth Muscle PDF Author: E. Betz
Publisher: Springer Science & Business Media
ISBN: 364266427X
Category : Medical
Languages : en
Pages : 158
Book Description
This book contains the contributions and discussions of the second symposium on vascular smooth muscles held in Ttibingen in February, 1976. It provides an up-to-date review of the role of ions in the trans mission of signals from the perivascular space to the contractile ele ments of the smooth muscle cells. The various aspects are mainly discussed from a functional point of view and only few contributions concern the morphologic variations of cells .during varying ion activity. Special emphasis was placed on the significance of ion variations in the cerebral tissue and their rela tion to metabolic and nervous control of the brain vessels. It could be seen in this symposium that new techniques enabled the in vestigators to make considerable progress in the understanding of the actions and the interactions of ions on the membranes and on the inter nal structures of the smooth muscle cells if one compares the findings with the results of the previous symposium held in Ttibingen in 1972. It became evident that the insight into ionic actions enables the de velopment of powerful tools to be utilized in future therapy of dis turbances of local blood flow regulation. The participants of the symposium render thanks to the Dr. Thiemann GmbH in Ltinen, which supported the symposium and this publication in a generous way. Finally it is a pleasure of the Editor to thank the members of the Physiological Institute of Ttibingen for their encouragement in the ar rangement of the meeting.

Airways Smooth Muscle: Peptide Receptors, Ion Channels and Signal Transduction

Airways Smooth Muscle: Peptide Receptors, Ion Channels and Signal Transduction PDF Author: David Raeburn
Publisher: Springer
ISBN: 303487362X
Category : Medical
Languages : en
Pages : 278
Book Description


Oscillatory Flow Effects on Rat Aortic Smooth Muscle Cells

Oscillatory Flow Effects on Rat Aortic Smooth Muscle Cells PDF Author: Joachim Rapp
Publisher: diplom.de
ISBN: 3832400486
Category : Medical
Languages : en
Pages : 107
Book Description
Inhaltsangabe:Abstract: A cell culture System to mimic the circumferential expansion of the arterial wall was supplemented with a flow control System for model enhancement. The given System imposed uniaxial sinusoidal stretch (1 Hz) with a 10 % elongation to an elastic silicone substrate upon which rat aortic smooth muscle cells were cultured. Occurring fluid motion during a stretch experiment caused oscillating shear stress upon the Gell layer of approximately 0.6 dynes/cm2 (60 x 10-3 N/m2) and was controlled by the newly added oscillatory flow System. Experiments were performed and investigated at 0, 4, and 24 hours. Morphological observations correlated with the results obtained by the initial stretch experiments. A final median angle of orientation of 60° - 70° from the axis of stretch was observed. Both control cultures remained randomly oriented throughout all experiments. Inhibition of cell proliferation alter 4 hours of cyclic stretch, observed by Karen J. Schnetzer could not be confirmed. However, growth related results did correspond to the preceding study in a qualitative manner. Influences of oscillatory flow an SMC growth and morphology were not different to the steady-stretch control. Analysis of results confirmed the assumption made for the earlier culture system, that effects of oscillatory fluid motion occurring during the cyclic stretch experiment could be neglected. Inhaltsverzeichnis:Table of Contents: AcknowledgmentsV List of FiguresIX List of TablesXI List of SymbolsXIII 1.Introduction1 2.Background and Literature Review3 2.1Arterial Anatomy4 2.2Arterial Physiology6 2.3Arterial Mechanics7 2.3.1Tensile Stress and Arterial Wall Deformation7 2.3.2Shear Stress8 2.4Arterial Pathology10 2.4.1Atherosclerosis10 2.4.2Hypertension12 2.4.3Smooth Muscle Cells in Arterial Disease12 2.5Cell Culture Models of Arterial Mechanics13 2.5.1Shear Models14 2.5.2Stretch Models14 3.Materials and Methods17 3.1Stretch Chamber17 3.1.1Demands on the Stretch System18 3.1.2Stretch Chamber Design19 3.2Flow Chamber20 3.2.1Mathematical Description of the Flow22 3.2.2Demands on the Flow Chamber27 3.2.3Flow Chamber Design27 3.3Elastic Substrate31 3.3.1Silicone Membranes31 3.3.2Extracellular Matrix33 3.4Cell Culture35 3.4.1Smooth Muscle Cells36 3.4.2Culture. Procedures37 3.5Experimental Set-Up40 3.5.1Equipment Preparation40 3.5.2Substrate Preparation41 3.5.3Cell Seeding Method43 3.5.4Stretch and Flow Chamber [...]

Vascular Intervention

Vascular Intervention PDF Author: Bruce A. Perler
Publisher: Thieme
ISBN: 9780865776944
Category : Medical
Languages : en
Pages : 733
Book Description
In this important new book, you'll get a full picture of vascular medicine today. The book covers all recent technological advances - including color-flow Doppler, duplex-graft surveillance, & intravascular ultrasound - & focuses on the interdisciplinary team approach as the key to patient care.

Smooth muscle and stromal tumors and prevention of inadequate surgery

Smooth muscle and stromal tumors and prevention of inadequate surgery PDF Author: Günter Köhler
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110351978
Category : Medical
Languages : en
Pages : 447
Book Description
Volume 1 of the 2-volumes-handbook provides a detailed description of epidemiology, etiology, pathological anatomy, prognosis, diagnosis, differential diagnosis, imaging and comprehensive therapy of genital leiomyosarcoma, low- and high-grade endometrial sarcomas, undifferentiated sarcoma, variants of leiomyoma, atypical smooth muscle tumors and rare stromal tumors including a separate chapter about prevention of inadequate sarcoma operations.

American Journal of Respiratory Cell and Molecular Biology

American Journal of Respiratory Cell and Molecular Biology PDF Author:
Publisher:
ISBN:
Category : Cell respiration
Languages : en
Pages :
Book Description


Human Physiology and Mechanisms of Disease

Human Physiology and Mechanisms of Disease PDF Author: Arthur C. Guyton
Publisher: Saunders
ISBN:
Category : Science
Languages : en
Pages : 690
Book Description
Intended for health science students and undergraduates, this book covers the basic physiology of common human disorders. Topics discussed include motor control of the body, the parathyroid hormone, calcium and phosphate metabolism and electrocardiographs in the diagnosis of heart abnormalities.

Handbook of Physiology: The cardiovascular system

Handbook of Physiology: The cardiovascular system PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description